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The increased angiogenesis under SMG aligns with previous reports of vascular remodeling in zebrafish larvae due to changes in NO 38

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With juveniles being chiefly afflicted, it can transpire between 30 and 50-year populations [143]

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On the target cell surface, IGF1 binds IGF1R which auto-phosphorylates and activates a signaling cascade mediated by the phosphorylation of the Insulin receptor substrate (IRS) proteins and other effectors leading to the activation of Mitogen-activated protein kinase (MAPK) and PI3K/AKT signaling pathways