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J Biol Chem 1929;82:345-367

The MTHFR gene has been identified to possess 14 common or rare single nucleotide polymorphism that are associated with enzymatic deficiency 14

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Eventually, a primary dysfunction of NMDARs, or neuroinflammation, or mitochondrial dysfunction, or impaired regulation of antioxidant systems could involve in turn the other vicious circles, all converging to common deleterious impacts on PV neurons and oligodendrocytes during neurodevelopment (Fig

Processed CITE-seq/scRNA-seq (rds file) and metabolomic data are available in the Figshare database under accession number Source data are provided with this paper

Serum IGF-1 levels appeared to start tapering down over the next 11 months after they peaked in month 1