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The Age-Related Eye Disease Studies (AREDS and AREDS2) remain the most influential trials in this context, demonstrating that specific combinations of antioxidants and minerals can reduce the likelihood of progression to advanced AMD in selected patient populations ( Although some studies suggest additive or synergistic effects when nutraceuticals are used alongside pharmacologic agents (Lafuente et al., 2019), definitive conclusions remain elusive due to the limited number of well-controlled trials designed to test such combinations

followed 44 patients after a successful SPK for up to 8 years