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At the cellular level, LPS-treated intestinal epithelial cells exhibited marked apoptosis accompanied by profound mitochondrial structural and functional impairment

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NH2-triP is then transformed into 6-pyruvoyltetrahydrobiopterin (6-PTP) by 6-pyruvoyl tetrahydrobiopterin synthase (PTPS), and finally, 6-PTP is reduced to BH4 via three successive reactions catalyzed by sepiapterin reductase (SPR)

Saleh, J., Peyssonnaux, C., Singh, K

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Nature 463: 364368 Heiden Vander MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM et al (2011) Metabolic pathway alterations that support: cell proliferation