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When NNMT is overactive as it tends to be in fat tissue, and increasingly with age and obesity it siphons off the very raw material your cells need to keep NAD+ topped up

References & Citations Aronne LJ, Sattar N, Horn DB, et al

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10.1016/j.heares.2009.03.004 11 CoffinA

Later, in June 2021 , the FDA approved a higher-dose formulation named Wegovy , explicitly t argeted at chronic weight management in patients without diabetes
