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Evidence from patients with HD and from rodent models implicates brain-derived neurotrophic factor (BDNF)-TrkB signalling deficiency in the pathogenesis of HD 10

Placebo A substance or treatment that has no therapeutic effect used as a control treatment in randomized controlled trials

It is needed to convert T4 into active T3 for proper metabolic activity

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Integration of the genomic 36,37 , transcriptomic 38 , and proteomic 39 data obtained for cancer cell lines of the CCLE and stored in the DepMap database 40 showed that both the transcript and protein abundance of p62 increase with aneuploidy score, which is defined as the number of chromosome arm-level aberrations 41 (Fig