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In all cases, the accessory protein directly associates with Retromer through presentation of PL motifs to the same hydrophobic pocket in VPS29 that accommodates PL motifs from TBC1D5, ANKRD27 and the FAM21 subunit of the WASH complex 44,77,82,114

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Consistent with this observation, permutational multivariate analysis of variance (PERMANOVA) revealed no statistically significant global difference between ASD and control metabolomic profiles ( p = 0.128)

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Your treatments will be adjusted based on your results as you move through the treatment process