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Diabetes Care 39 , 222230 (2016) L.A

Subsequent identification of JWU-A021 as a TRPA1 channel activator was achieved at the Holz laboratory in a fura-2-based secondary screen that used a panel of calcium channel blockers or activators

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Metabolism & Elimination The metabolic fate of GLP3 has been partially characterized in clinical pharmacology studies[17]: Mean elimination half-life of approximately 6 days in healthy adults and patients with type 2 diabetes Hepatic metabolism represents the primary clearance pathway Does not interact with cytochrome P450 enzyme systems, minimizing potential drug-drug interactions Likely undergoes peptidase-mediated degradation and proteolytic cleavage The three non-coded amino acid modifications confer resistance to dipeptidyl peptidase-4, contributing to extended half-life The prolonged half-life enables once-weekly dosing while maintaining therapeutic drug concentrations throughout the dosing interval, with minimal peak-to-trough fluctuations that could contribute to side effects or reduced efficacy