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Glutamine is naturally present at high concentrations in human tissues and plasma, and its degradation (via glutaminolysis) provides fuel for the tricarboxylic acid (TCA) cycle and building blocks for essential biosynthetic processes, such as lipid biosynthesis

Similarly, the upregulation of cysteine dioxygenase 1 (CDO1) was shown to increase vulnerability to ferroptosis by inducing cysteine catabolism and, by extension, GSH depletion [24]

In adulthood, ROS contribute to immune responses, tissue repair, and adaptation to environmental challenges

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These values provided a prediction about BBB permeability, with a candidate that could be targeted to the CNS with a PSA cutoff value of 90 2 or below [37]