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It plays a key role in the mitochondria the powerhouses of the cell where it supports the production of ATP (adenosine triphosphate), essential for energy generation

Mol Cell Biochem (2014) 386:7383

Although the mechanisms of action and molecular target(s) of these chemotherapeutic agents are diverse and include both DNA and microtubular targets to arrest cell division and induce cell death, the pathobiology of chemotherapy-induced neuropathy, irrespective of the causative agent, shares some important similarities

Therefore, more recent research has shifted the focus to screening a drug that targets the lipotoxicity of individuals with fewer side effects to prevent and treat KOA [10, 11]

Curr Ther Res 1985;38:256-264

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