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[DOI] [PubMed] [Google Scholar] 81.Goodwin J.E., Feng Y., Velazquez H., Sessa W.C

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Moreover, NAMPT activity is crucial for the beneficial effects of calorie restriction, including improved oxidative stress management, mitochondrial biogenesis, and metabolic adaptation, as reported in a study involving Sprague-Dawley rats 213

Gene expression analysis revealed Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased 2.1-foldall statistically significant changes indicating re-entrainment of disrupted circadian oscillations