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In the smoking cessation trial of Prado and colleagues, there was a significant reduction in depression [134], a secondary outcome also seen in the post- traumatic stress disorder trial of Kalivas and colleagues [99]

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While we observed some weight loss in vivo, this is likely related to an appetite-reducing effect as has been observed for metformin 78 , the weight trend reassuringly did not change post-infection

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In the Phase 2/3 portion of Study 2, based on data accrued through November 14, 2020, approximately 44,000 participants 12 years of age and older were randomized equally and received 2 doses of Pfizer-BioNTech COVID-19 Vaccine (30 mcg modRNA) or placebo separated by 21 days
