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In this review, we describe the central roles of mitochondria in oxidative stress, inflammation, and aging, especially mechanisms in diseases, and the current mainstream drugs targeting mitochondria

Changes in the composition of brain interstitial ions control the sleep-wake cycle

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This facilitates transmembrane flow of Na + , K + , and Ca 2+ , inducing cell membrane depolarization and activating downstream signaling cascades (Figure 2) ( 4 2 receptors are widely distributed in the VTA, NAc, and prefrontal cortex, playing a central role in regulating dopamine release and reinforcement learning ( 7 receptors are primarily localized in dopaminergic neurons and participate in modulating long-term potentiation of glutamatergic neurons ( 4 2 and 6 2 3 complexes

[DOI] [PubMed] [Google Scholar] 5.Stewart W.F., Wood C., Reed M.L., Roy J., Lipton R.B

The effect was dose-dependent (more BPC-157, more receptors) and time-dependent (longer exposure, more receptors)