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for example, increasing the therapeutic-to-matrix ratiothereby raising the initial drug input and potential loadingoften results in a marked reduction in encapsulation efficiency (Xu and Hanna, 2006)

The therapeutic PAM-HA polymer carrier could increase joint lubrication and reduce oxidative stress

SHMT also catalyzes the endogenous synthesis of lysine from glutamate or glucose

Mahadevan and Palsson, 2005

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Anti-ferroptotic compounds that reduce oxidative stress include liproxstatin 1 (Lip-1) (inhibitor of ROS and lipid peroxidation), chalcones 14a-c (inhibitor of A and lipid peroxidation), Selenomethionine (Se-Met) (inhibitor of lipid peroxidation), CMC121 (fatty acid synthase inhibitor), N -acetylcysteine (NAC) (free radical scavenger), Vitamin E (Vit E) and PD146176 (15-LOX-1 inhibitor)