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This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity

This again points to the importance of the interaction between proteasome function and mitochondrial homeostasis

Given the importance of the cofactor in energy metabolism, NAD + is especially important in mitochondrial function, and in fact both NAD + and mitochondria are concentrated in energetically demanding tissues 1012