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Nat Rev Immunol (2016) 16:32134

Thus, newborn Keap1 -knockout mice (in which Nrf2 is constitutively overexpressed) die from hyperplastic keratinization of the oesophagus and forestomach, which obstructively limits intake of food

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When ROS levels rise and threaten the homeostatic processes of the human body, endogenous antioxidants are activated