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Patients were excluded if they were discharged before MTX clearance (defined as 0.1 M) or if they received HD-MTX as part of a pediatric protocol, as many of these protocols have unique nomograms

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Patent 9,643,930 Tern MD, Besada PP, Costas CT , Costas LD, Vila MN, Via CD (2019) Pyridazin-3(2H)-one derivatives as monoamine oxidase selective isoform B inhibitors

Schedule: Daily subcutaneous injections for 812 weeks (extend to 16 weeks if research goals require)