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Generally, hydrophobic residues form essential contacts during protein-protein interactions, whereas acidic residues mediate long-range interactions with positively charged residues 50-53

Clin Endocrinol 40:393400 Jrgensen JO, Pedersen SA, Thuesen L, Jrgensen J, Ingemann-Hansen T, Skakkebaek NE, Christiansen JS (1989) Beneficial effects of growth hormone treatment in GH-deficient adults

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Further analysis suggested that the peptide may have increased the ratio of Bcl-2/Bax, and potentially decreased cleaved caspase-3 and PARP levels, two markers of cell death

In some embodiments, mucoadhesive characteristics are also imparted to otic formulations disclosed herein, by incorporation of mucoadhesive carbomers, such as Carbopol 934P, to the composition (Majithiya et al., AAPS PharmSciTech (2006), 7(3), p

The solvent affects the peptides solubility and stability, so its important to follow the guidelines provided for each peptide