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ATF4 siRNA produced a 50% decrease in ATF4 mRNA that was sufficient to blunt but not block the MR-induced increases of some ATF4 target genes (e.g., ASNS, CHAC1, DDIT4, FGF21), while fully inhibiting MR-induced increases of other ATF4 target genes (e.g., CARS, MARS, EIF4EBP1, PSAT1, and SESN2) (Fig

All experimental groups showed a progressive decrease in latency when the platform was below the water surface (Fig

This transformation disrupts the hydrogen bonding in bilirubin, converting it into a hydrophilic molecule that cannot be reabsorbed by hepatocytes or intestinal epithelium, thus promoting its excretion [24, 25]

RNA seq analysis also exhibited the silent behavior of these three genes in all cultivars

doi: 10.1128/mBio.01291-18 28 BicanicT.BottomleyC.LoyseA.BrouwerA