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Using this mechanistic model of bile acids, we explain how abnormal bile acid physiology drives disease pathogenesis, emphasizing how ceramide synthesis may serve as a unifying pathogenic feature for cardiometabolic diseases

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Treatments include foliar application of lead at two levels (0.0 and 1 mmol) as lead acetate, foliar application of liquid sulfur at two levels (0.0 and 2 per thousand), and foliar application of amino acids at four levels (0.0, serine at 200 mg/L, glutamine at 200 mg/L, and co-application of serine and glutamine at the same concentrations) at pre-flowering stage

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