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2 Western medical understanding of POI 2.1 Definitions POI refers to the decline in ovarian function in women before the age of 40, characterized by infrequent menstruation or amenorrhea, accompanied by elevated FSH levels and decreased E2 and AMH levels, constituting a clinical syndrome ( Figure 1 )

Hence, the reduction of the GSH level by both drugs might also reflect to some extent beginning tumor necrosis

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