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Only 11 of 17 products selected for testing met quality criteria for freshness and labeling

Structurally related to the acyloxyalkyl prodrugs are carbonate esters, most commonly isopropyloxycarbonyloxymethyl (POC) protected phosphonates (Figure 4)

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10.1159/000346195 46 GorlovaO.MartinJ.-E.RuedaB.KoelemanB

While early rodent studies suggested alternating hypothalamic GHRH and somatostatin burst as primary drivers of GH pulsatility, other data implicated somatostatin as the key regulator of secretory timing and amplitude, with tonic GHRH secretion [16,17,18,19]

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