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Disorders that affect the gastrointestinal pH can also result in malabsorption and thus vitamin B 12 deficiency

Notably, the lack of schistocytes and a normal Coombs test support the conclusion that the anemia resulted from ineffective erythropoiesis rather than actual hemolysis

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This implies that a significant proportion of patients with diabetes who regularly use metformin take acid-suppressing medications, potentially increasing the risk of developing a vitamin B12 deficiency [17,50]
