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Indeed, in animal models, enhanced neurogenesis after regular physical exercise has been reported, whereas stress (acute or chronic) is known to decrease this process [110,111,112]

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Studies report that the PBPK model can be applied to predict the course of all parent substances, metabolites, and some biomarkers in the studied organism, incorporating mechanistic data related with the absorption, distribution, metabolism, and excretion (ADME) properties [134,135,136,137]

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559 Further analysis revealed that cognitively impaired GPX4BIKO mice experienced neurodegeneration and increased lipid peroxidation in the hippocampus