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With aging, the gradual accumulation of atherosclerotic risk factors, including oxidative stress, inflammation, dyslipidemia, and hyperglycemia, drives metabolic reprogramming in ECs, particularly in regions exposed to disturbed flow with OS, ultimately leading to EC dysfunction and atherosclerosis

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N-acetyl cysteine (NAC) is a supplement derived from cysteine, a sulfur-containing amino acid that is crucial for the synthesis of glutathione