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MOTS-c promotes NRF2 activation, upregulating genes for glutathione synthesis, superoxide dismutase, and catalase [3]
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Other manifestations, such as Marburg disease, Schilders disease and Bals concentric sclerosis are mostly understood as specific variants of those diseases ( As already stated, the clinical differentiation between these diseases occurs through lesion topography, disease course and, in certain cases, as NMOSD and MOGAD, by a biological biomarker

Extrinsic skin aging expedites aging through environmental factors, causing thickening of the epidermis, decreased proliferation of basal cells, collagen downregulation, and increased oxidative stress [81]
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