glutathione kidney toxicity Kidney-based in vitro models for drug-induced testing | Archives of Toxicology Most kidney patients season their
Description
This GSH acts as a co-substrate for glutathione peroxidase (GPX)-catalyzed reactions, aiding in the removal of hydrogen peroxide (H2O2) and lipid hydroperoxides and generating its oxidized form, glutathione disulfide (GSSG) [15]
New England Journal of Medicine 2006;355:20910
"Antioxidant mechanisms of glutathione in skin protection: From molecular pathways to clinical applications." Free Radical Biology and Medicine, 168, 187-202.
Hydrogen peroxide may also be converted to the potent oxidant hypochlorous acid in the presence of the chloride ion
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Maddalena, G, van der Pol, Y, Rivers, Z, Dasari, NV, Rogers, JE, Guinney, J, Kopetz, S , Raghav, KS
