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The results showed that loss of GSTA4 significantly decreased cell proliferation and clonogenicity, whereas it increased intracellular reactive oxygen species and cell susceptibility to 5-fluorouracil (5-FU) and oxaliplatin

Natural killer cell cytotoxicity increased significantly in the high-dose group and non-significantly in the low-dose group after three months of supplementation
A recent US nationally representative data indicates a MetALD prevalence of 2.56%, with worse survival than MASLD

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These findings suggest that both NNMT and its product MNA increase Sirt1 protein expression, while Sirt1 is needed for the regulatory effects of NNMT and MNA on glucose metabolism [14]
