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Nitrous oxide misuse can cause vitamin B12 deficiency and absorption issues, which can lead to nerve damage, paralysis, chronic numbness, and loss of coordination

143 It seems likely that these protective effects could be optimised if metformin-induced vitamin B12 deficiency could be avoided

Martinez V, Forr C, Weydert S, et al
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Vitamin B12 may improve energy levels and support cognitive function, heart health, nerve repair, and neuropathy reduction

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