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In contrast, the AKT1 protein was up-regulated in the low-dose silymarin group and down-regulated in the high-dose silymarin group, along with IL-6, MAPK1, Caspase 3, p53, and VEGFA proteins

Wilber RL

10.1016/0022-2828(90)90984-a 115 KumarS.DikshitM

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Regulatory monitoring has recorded two serious adverse events in the FDAs FAERS database (2021, 2023) and one life-threatening event in the CAERS database

GSH mediates the regulation of redox-dependent pro-inflammatory cytokines, such as IL-9 and TNF- and also has vasodilator properties by increasing cyclic GMP levels and by contributing to the regeneration of endothelial-derived relaxing factor (EDRF), reducing the inflammatory state [27]