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In chronic migraines, Botox is believed to function by inhibiting pain-signaling transmission between the head and neck and the central brain, where migraines are generated

10.1016/j.tibs.2017.10.006 Trends Biochem Sci

Although we do not yet understand the precise structural basis of this process, the results we present here demonstrate a link between the activation of GABA A Rs and the potentiation of inhibitory synapses not only providing an important insight into the plasticity of inhibition in the brain, but also revealing the potential of the GABA A R to signal its level of activation (desensitization) by engaging with a metabotropic signalling pathway at inhibitory synapses

Vaccine 24 , 10281034 (2006)

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