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Defense mechanisms include, for example, the reduction of ROS by antioxidant enzymes such as catalase, manganese-, copper- and zinc-containing superoxide dismutase (Mn-SOD/Cu-SOD/Zn-SOD), and the redox-sensitive enzyme glutathione peroxidase [2, 3, 13, 1619, 27, 37]

Thirdline options like NMDA receptor antagonists or cannabinoids are reserved for refractory cases

Expression of the ENO2 gene is restricted to nervous tissues

Mutagenic primers [Sigma-Aldrich (Oakville, ON) or Integrated DNA Technology (Coralville, IA)] were designed to generate four individual Cys to Ser mutants (V5_GSTP1-C15S, V5_GSTP1-C48S, V5_GSTP1-C102S, V5_GSTP1-C170S) (primer sequences available upon request)

6 RNAi-independent function of Dicer-2: regulation of translation Besides an essential role in RNAi for the control of parasitic nucleic acids, Dicer-2 has also emerged as a key regulator of other cellular processes such as stress resistance (138)

306 Even if not yet reported in the literature, the same reactions can occur with other C18-PUFAs including GLA, forming 6-, 9-,10-, and 13-HpOTrE-, and SDA, forming 6-,9-,10-,12-, 13-, and 16-HpOTE