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There currently are only five provider and supplier types that fall within the high categorical risk level under 424.518(c)(1): newly/initially enrolling opioid treatment programs that have not been fully and continuously certified by SAMHSA since October 23, 2018 (hereafter collectively referenced as simply OTPs unless specified otherwise)

2005 Jul 20;(3):CD004655

Aust N Z J Psychiatry

The deadline for submission of comments is on 22 May 2026

It has not undergone Phase I, II, or III human clinical trials and is not recognized as Generally Recognized as Safe (GRAS)

Plant Cell 17:268281 De Gara L, de Pinto MC, Tommasi F (2003) The antioxidant systems vis--vis reactive oxygen species during plant-pathogen interaction