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Although the study was small, there were signs of potential benefit in patients who received the mRNA had certain trends toward improved cardiac function compared to placebo, though the trial was not designed for definitive efficacy conclusions [108]

Potential compounds Numerous preclinical studies testing mitochondria targeted compounds have indicated that the direct delivery of mitochondrial drugs to the brain is achievable through the intranasal route (Table 1)

Wang XY, Liu WG, Hou AS, et al

Oxidative Med Cell Longev 2018:9719584

174 Comparable studies in mice with the cardiomyocyte-specific over-expression of CYP2J2 and subjected to TAC or ISO infusion revealed that enhanced cardiac EET biosynthesis is protective against electrical remodeling, ventricular tachyarrhythmia, and atrial fibrillation associated with cardiac hypertrophy