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Long-chain fatty acids (LCFAs) cannot directly cross the mitochondrial membrane because of their high polarity and are activated to long-chain acyl-CoA by acyl-CoA synthetase (ACS)

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The mechanisms of migraine are complex, involving many factors including serotonin and CGRP

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Furthermore, TMAO induces reactive oxygen species (ROS) generation in macrophages, creating a feed-forward loop that amplifies both inflammatory responses and oxidative stress ( 4.2 Impact of TMAO on DCs DCs, as the most potent professional antigen-presenting cells in the body, play a pivotal role in antigen recognition and signal transmission during immune response

S.PandyaK.StoycheffN.OkparaveroA.GreeneT.et al (2014)