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The fact is that GP audits (and no clinical evidence or patient involvement of any kind) eventually made three monthly injections the optimal maintenance dose of B12

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This type of pain is typically well localized, with the intensity often exacerbating with movement or mechanical stress and tending to diminish with the healing of the affected tissues

Therefore, it is intriguing to speculate that pathological alterations of substrate-product ratio of metabolic enzymatic reactions might have an impact on the availability of intermediates involved in PTMs of TFs and, consequently, modify the cellular transcriptional landscape

One key way is through its impact on metabolism