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Some studies report modest increases in lean mass (1-3 kg over 6 months), while others show maintenance of lean mass rather than significant gains

Total T lymphocyte counts were found in a study of 32 patients to be lower than in controls (Ritchie et al., 1984), due largely to a deficit of T helper cells but not T suppressor-cytotoxic cells

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They postulate that fibroblast migration is based on a modulating circuit with interactions between SHH signaling genes, Smoothened, Gli1, and -catenin [99]