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doi: 10.1038/s41467-020-15546-9 97 DaviesHBignellGRCoxCStephensPEdkinsSCleggSet al

The epidermal melanocytes are then stimulated to produce melanin as the tyrosinase inhibiting effect of GSH has been diminished.[9] So, the predominant mechanism of hyper pigmentation in vitamin B12 is hypothesised as 1) Deficiency of vitminB12 decreases the level of reduced glutathione, which activate tyrosinase and thus leads to transfer to melanosomes

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