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However, the challenge was that such compounds could not easily penetrate cell membranes
[DOI] [PMC free article] [PubMed] [Google Scholar] 278.Martins ET, Baruah H, Kramarczyk J, Saluta G, Day CS, Kucera GL, Bierbach U

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In summary, tweaking the reaction conditions to find a window in which the AON can be modified but not degraded was crucial to allow for this AON functionalisation protocol

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