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Two collagen types dominate: Type I collagen (mature tendon structure) Type III collagen (early repair phase) In rodent studies, BPC-157-treated tendons showed: Increased type I collagen deposition Improved fiber parallel alignment Better biomechanical strength This suggests influence over: TGF- signalling Matrix metalloproteinases (MMPs) Extracellular matrix remodelling enzymes Balanced ECM remodelling prevents disorganized scar tissue

Gene set enrichment analysis Fast gene set enrichment analysis (fgsea) was implemented to score pathway enrichment 69

[PMC free article: PMC2828367] [PubMed: 16495485] 531

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Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration

consequently creating a cellular oxidative environment which triggers the oxidation of essential biomolecules like DNA, protein and lipids, leading to multiple disease conditions