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Using isobutyryl-CoA as the substrate, FAS/FASN-1 generates C13:iso, which may be conversed to C15:iso or C17:iso via the actions of the elongases (ELO-5 and/or ELO-6) and 3-ketoacyl-CoA reductase (LET-767)
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& Oehninger, S
Hum Mol Genet 20:26032610
The narrow surgical margin used (smaller than the standard of care of 5 mm), combined with the limitation of the standard bread loafing technique of fixed tissue histology - result in a high "false negative" error rate, and frequent recurrences
F., Lobine, D., Akram, M., Riaz, M., Capanoglu, E., Sharopov, F., Martins, N., Cho, W
