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Recent scRNAseq studies of human lung fibrosis have identified two categories of AMs: pro-inflammatory and pro-fibrotic 20,26,27 .These macrophage subsets contribute to fibrosis by secreting cytokines, chemokines, and reactive oxygen species, which in turn promote fibroblast activation, collagen deposition, and tissue remodeling within the alveolar interstitium

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Certain medicines that decrease the stomach's acid production, such as omeprazole, lansoprazole, pantoprazole, etc., are used to treat gastric reflux(6)

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Patients often suffer from chronic LBP that may radiate to the buttocks or legs, impairing daily activities