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In addition to the complexity of the PDHc at the level of the total number of protein subunits (30 subunits of E1, 60 subunits of E2, and 12 subunits of E3), the full activity of the PDHc requires five different vitamin-derived coenzymes: CoASH, NAD + , FAD, lipoic acid, and thiamine pyrophosphate (TPP)

She experienced chronic pain, numbness, fatigue, and balance problems that were repeatedly dismissed or misdiagnosed

doi: 10.3389/fnagi.2022.881239 31 ChenH

Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion

Specifically, SOD facilitates the conversion of superoxide anions into hydrogen peroxide, which is subsequently broken down by CAT and GSH-Px

Bhamidipati D, Singh Raghav KP, Morris VK, Kopetz S , Kee BK, Johnson B, Willis J, Dasari A, Morelli MP, Parseghian CM, Lee MS, Le P, YC Shen JP, Ludford K, Overman MJ