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These are not routine for every patient

Phase I study of a systemically delivered p53 nanoparticle in advanced solid tumors

Detailed analysis of atpenin A5 and phenformin cytotoxicity and inhibition of metabolic activity in various cell lines As predicted from our modeling approach as tier 1 targets, atpenin A5 at 20 M and phenformin at 100 M do not show toxicity in endpoint measurements based on total cell counting when Calu-3, CaCo-2, A549, and Huh7.5 cells were exposed to the compounds for 72 h (Fig

PubMed:9278457)

Mechanisms include oxidative stress reduction and improved neuronal health

doi: 10.1093/humrep/dey015