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For instance, pH-sensitive systems exploit the acidic milieu of inflamed or ischemic brain regions (pH 6.56.8) and endolysosomal compartments (pH 4.56.0) to trigger disassembly of polymeric micelles, liposomes, or dendrimer hybrids loaded with curcumin, resveratrol, or withanolides

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In contrast, the NMDA antagonist (memantine) or the tetracyclic antidepressants (mirtazapine and mianserin) seem to be more suitable for adjunctive therapy of cognitive impairment and mood disorders of BPSD, respectively

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