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10.1016/j.celrep.2014.11.016 185 OwusuB

Increased TSH fosters cAMP synthesis, which in turn initiates cAMP-dependent protein kinase signaling systems, to potentiate EGF-mediated cell proliferation, stimulating thyroid cell growth and promoting tumor cell proliferation, invasion and metastasis (8688)
It's also popular for anti-aging, as it protects cells and mitochondria from oxidative damage, which is a key factor in the aging process

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We utilized Superscript III reverse transcriptase enzyme (Invitrogen) with random hexamer primers and 3 g of RNA from each sample to produce cDNA according to the manufacturers protocol
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