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Nature Rev Immunol 5:641654 Burns RA, Milner JA, Corbin JE (1981) Arginine: an indispensable amino acid for mature dogs

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[13] There are no safety data regarding the use of nicotinic acid in doses above the RDA during breast-feeding

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Due to the relatively rapid kinetics of NOS2-dependent PDH shutdown during macrophage polarization, as well as the apparent lack of involvement of HIF-1 in enzyme inhibition 6 , we hypothesized that NO might directly target components of the PDH complex