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A review of nearly 40 animal studies using doses ranging in human equivalents from 70mg to 60g daily saw consistent benefits for cognitive impairment.5 Another study in mice looking at rhodiolas potential for neuroprotection found that crude extract and isolated bioactive compounds all provided benefits, though high doses of isolated bioactive compounds performed better.6 Rhodiola to improve mood A prominent rhodiola study for depression also used the SHR-5 extract, delivering 3% rosavins and 1% salidrosides.7 At doses of 340mg and 680mg per day, participants saw improvements in depression scores, insomnia, and emotional stability

Andrade MC, Albernaz MJ, Arajo MS, Santos BP, Teixeira-Carvalho A, Faria AM, et al

Salvianolic acid B, a rosmarinic acid dimer, is an active component of Salvia miltiorrhiza Bunge [Lamiaceae], and its reduction of drug-induced liver injury is associated with its antioxidant activity (Lin et al., 2015)

Antioxidant systems, such as the glutathione (GSH) pools, regulate redox status in cells to guard against such damage

As example, an analytical approach for the determination of S-glutathionylated proteins based on the specific reduction of mixed disulfides by Grx, their reaction with N-ethylmaleimidebiotin, followed by affinity purification on avidin-agarose of tagged proteins and identification by proteomic analysis has been developed [129]

Vox Sang 91 , 1319 (2006)