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For the brain, where the same mechanism operates, this results from a rise of intracellular calcium concentration, [Ca 2+ ], triggering pericyte contraction during ischaemia, with subsequent pericyte dysfunction or death maintaining the constriction when the arterial blood supply is restored 9

Like other weight loss drugs, tirzepatide promotes weight loss by affecting certain brain chemicals involved in food intake, energy expenditure, and fat deposition

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[DOI] [PubMed] [Google Scholar] 35.Sindhu S., Thomas R., Shihab P., Sriraman D., Behbehani K., Ahmad R

Effect on hemoglobin A1c (HbA1c) and body weight after discontinuation of tirzepatide, a novel glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist: A single-center case series study