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The onset of these symptoms, generally 24 hours or more after the transdermal system has been removed, can be severe and may require medical intervention [see Warnings and Precautions (5.6)]

Involvement of the cystathionine pathway in the biosynthesis of glutathione by isolated rat hepatocytes

Animals were housed at a controlled temperature (23 C) and controlled lightdark cycle (1212 h), with free access to water and food 16,17

Nan Fang Yi Ke Da Xue Xue Bao 43 , 17761781 (2023)

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This hormonal sensitivity explains why certain scalp regions are affected while others, like the back and sides, typically remain resistant throughout life